Implementation of adaptive methods in early-phase clinical trials
نویسندگان
چکیده
منابع مشابه
Adaptive dose insertion in early phase clinical trials.
BACKGROUND AND PURPOSE We propose to adaptively insert new doses during the course of a dose-finding trial when none of the prespecified doses in the trial are acceptable, for example, have tolerable toxicity. METHODS Our procedure uses an activation rule to determine whether a new dose is needed and an inverse dose-response algorithm to estimate new doses to be inserted into the trial. RES...
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The majority of Phase I dose-finding trials in oncology have been dominated by the traditional up-and-down designs, such as 3+3 designs. However, in recent years, there is an emerging interest in more innovative model-based dose finding methods such as the Continual Reassessment Method (CRM), though examples of implementing such adaptive designs in the medical literature remain limited. In this...
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ژورنال
عنوان ژورنال: Statistics in Medicine
سال: 2016
ISSN: 0277-6715
DOI: 10.1002/sim.6910